{"id":7370,"date":"2024-02-18T16:47:18","date_gmt":"2024-02-18T15:47:18","guid":{"rendered":"https:\/\/www.em-grade.com\/sem-categoria\/fixador-de-karnovsky\/"},"modified":"2024-02-18T16:47:18","modified_gmt":"2024-02-18T15:47:18","slug":"fixador-de-karnovsky","status":"publish","type":"post","link":"https:\/\/www.em-grade.com\/pt-pt\/fixadores\/fixador-de-karnovsky\/","title":{"rendered":"Fixador de Karnovsky"},"content":{"rendered":"<h1 class=\"entry-title\">Fixador de Karnovsky<\/h1>\n<p><strong>Misturas que cont\u00eam formalde\u00eddo e glutaralde\u00eddo , esta mistura \u00e9 frequentemente designada por fixador de Karnovsky <\/strong><br \/>\nA combina\u00e7\u00e3o de formalde\u00eddo com glutaralde\u00eddo como fixador para microscopia eletr\u00f3nica tira partido da r\u00e1pida penetra\u00e7\u00e3o<a href=\"https:\/\/www.em-grade.com\/wp-content\/uploads\/2024\/02\/hepatocyte-after-Karnovsky-fixative.jpg\"><img alt=\"\" loading=\"lazy\" decoding=\"async\" class=\" wp-image-4419 alignright\" src=\"https:\/\/www.em-grade.com\/wp-content\/uploads\/2024\/02\/hepatocyte-after-Karnovsky-fixative-150x150.jpg\" alt=\"\" width=\"298\" height=\"298\" srcset=\"https:\/\/www.em-grade.com\/wp-content\/uploads\/2024\/02\/hepatocyte-after-Karnovsky-fixative-150x150.jpg 150w, https:\/\/www.em-grade.com\/wp-content\/uploads\/2024\/02\/hepatocyte-after-Karnovsky-fixative-140x140.jpg 140w, https:\/\/www.em-grade.com\/wp-content\/uploads\/2024\/02\/hepatocyte-after-Karnovsky-fixative-100x100.jpg 100w, https:\/\/www.em-grade.com\/wp-content\/uploads\/2024\/02\/hepatocyte-after-Karnovsky-fixative-500x500.jpg 500w, https:\/\/www.em-grade.com\/wp-content\/uploads\/2024\/02\/hepatocyte-after-Karnovsky-fixative-350x350.jpg 350w, https:\/\/www.em-grade.com\/wp-content\/uploads\/2024\/02\/hepatocyte-after-Karnovsky-fixative-1000x1000.jpg 1000w, https:\/\/www.em-grade.com\/wp-content\/uploads\/2024\/02\/hepatocyte-after-Karnovsky-fixative-800x800.jpg 800w\" sizes=\"auto, (max-width: 298px) 100vw, 298px\" \/><\/a>de pequenas mol\u00e9culas de HCHO, que desencadeiam a estabiliza\u00e7\u00e3o estrutural do tecido. A reticula\u00e7\u00e3o r\u00e1pida e completa \u00e9 causada pelos olig\u00f3meros de glutaralde\u00eddo de penetra\u00e7\u00e3o mais lenta. <strong>Esta mistura est\u00e1 associada ao nome de Morris J. Karnovsky<\/strong> de Boston. Trata-se de um exemplo de uma grande inova\u00e7\u00e3o que s\u00f3 foi publicada num resumo n\u00e3o revisto (Karnovsky, 1965). A sua mistura original continha 4% de glutaralde\u00eddo, uma concentra\u00e7\u00e3o superior \u00e0 que muitos pretendiam utilizar (Hayat, 1981).    Designa\u00e7\u00f5es como<br \/>\n&#8220;Karnovsky a meia for\u00e7a&#8221; tornou-se linguagem comum nas d\u00e9cadas de 1960 e 1970. Os fixadores deste tipo permitiram descri\u00e7\u00f5es definitivas da histologia ao n\u00edvel do EM que foram realizadas nos 5 ou 6 anos seguintes \u00e0 introdu\u00e7\u00e3o do fixador de Karnovsky, e continuam a ser utilizados habitualmente.<\/p>\n<p>As refer\u00eancias<\/p>\n<p>Baker, JR (1958). Principles of biological microtechnology (reprinted in 1970, with corrections). London: Methuen.<br \/>\nCarson, FL, Martin, JH &amp; Lynn, JA (1973). Fixa\u00e7\u00e3o de formalina para<\/p>\n<p><a href=\"https:\/\/www.em-grade.com\/wp-content\/uploads\/2024\/02\/olive-leaf-wall-Karnovsky-solution-fixing.jpg\"><img alt=\"\" loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-4421\" src=\"https:\/\/www.em-grade.com\/wp-content\/uploads\/2024\/02\/olive-leaf-wall-Karnovsky-solution-fixing-150x150.jpg\" alt=\"\" width=\"364\" height=\"364\" srcset=\"https:\/\/www.em-grade.com\/wp-content\/uploads\/2024\/02\/olive-leaf-wall-Karnovsky-solution-fixing-150x150.jpg 150w, https:\/\/www.em-grade.com\/wp-content\/uploads\/2024\/02\/olive-leaf-wall-Karnovsky-solution-fixing-140x140.jpg 140w, https:\/\/www.em-grade.com\/wp-content\/uploads\/2024\/02\/olive-leaf-wall-Karnovsky-solution-fixing-100x100.jpg 100w, https:\/\/www.em-grade.com\/wp-content\/uploads\/2024\/02\/olive-leaf-wall-Karnovsky-solution-fixing-500x500.jpg 500w, https:\/\/www.em-grade.com\/wp-content\/uploads\/2024\/02\/olive-leaf-wall-Karnovsky-solution-fixing-350x350.jpg 350w, https:\/\/www.em-grade.com\/wp-content\/uploads\/2024\/02\/olive-leaf-wall-Karnovsky-solution-fixing-1000x1000.jpg 1000w, https:\/\/www.em-grade.com\/wp-content\/uploads\/2024\/02\/olive-leaf-wall-Karnovsky-solution-fixing-800x800.jpg 800w\" sizes=\"auto, (max-width: 364px) 100vw, 364px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fixador de Karnovsky Misturas que cont\u00eam formalde\u00eddo e glutaralde\u00eddo , esta mistura \u00e9 frequentemente designada por fixador de Karnovsky A combina\u00e7\u00e3o de formalde\u00eddo com glutaralde\u00eddo como fixador para microscopia eletr\u00f3nica&#8230;<\/p>\n","protected":false},"author":8,"featured_media":7371,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"itsec_x_frame_options":"","footnotes":""},"categories":[451],"tags":[711],"class_list":["post-7370","post","type-post","status-publish","format-standard","has-post-thumbnail","category-fixadores","tag-fixador-de-karnovsky"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.em-grade.com\/pt-pt\/wp-json\/wp\/v2\/posts\/7370","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.em-grade.com\/pt-pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.em-grade.com\/pt-pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.em-grade.com\/pt-pt\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.em-grade.com\/pt-pt\/wp-json\/wp\/v2\/comments?post=7370"}],"version-history":[{"count":0,"href":"https:\/\/www.em-grade.com\/pt-pt\/wp-json\/wp\/v2\/posts\/7370\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.em-grade.com\/pt-pt\/wp-json\/wp\/v2\/media\/7371"}],"wp:attachment":[{"href":"https:\/\/www.em-grade.com\/pt-pt\/wp-json\/wp\/v2\/media?parent=7370"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.em-grade.com\/pt-pt\/wp-json\/wp\/v2\/categories?post=7370"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.em-grade.com\/pt-pt\/wp-json\/wp\/v2\/tags?post=7370"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}